Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto N
PROVIDER: S-EPMC5591398 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Matsumoto Naoya N Satyam Abhigyan A Geha Mayya M Lapchak Peter H PH Dalle Lucca Jurandir J JJ Tsokos Maria G MG Tsokos George C GC
Frontiers in immunology 20170904
C3a is important in the regulation of the immune response as well as in the development of organ inflammation and injury. Furthermore, C3a contributes to liver regeneration but its role in intestinal stem cell function has not been studied. We hypothesized that C3a is important for intestinal repair and regeneration. Intestinal organoid formation, a measure of stem cell capacity, was significantly limited in C3-deficient and C3a receptor (C3aR) 1-deficient mice while C3a promoted the growth of o ...[more]