Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC5592152 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Jin Yafei Y Huang Xiaoqin X Papke Roger L RL Jutkiewicz Emily M EM Showalter Hollis D HD Zhan Chang-Guo CG
Bioorganic & medicinal chemistry letters 20170814 18
Starting from a known non-specific agonist (1) of nicotinic acetylcholine receptors (nAChRs), rationally guided structural-based design resulted in the discovery of a small series of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridines (3a-3e) incorporating a phenyl ring off the pyridine core of 1. The compounds were synthesized via successive Suzuki couplings on a suitably functionalized pyridine starting monomer 4 to append phenyl and pyridyl substituents off the 3- and 5-positions, respectively, and ...[more]