Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC5592373 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Wang Guangchuan G Zhou Hangyu H Nian Qing-Gong QG Yang Yuling Y Qin Cheng-Feng CF Tang Ruikang R
Chemical science 20151210 3
Exploring formulations that can improve the thermostability and immunogenicity of vaccines holds great promise in advancing the efficacy of vaccination to combat infectious diseases. Inspired by biomineralized core-shell structures in nature, we suggest a polyethyleneimine (PEI)-silica-PEI hybrid coated vaccine formulation to improve both thermostability and immunogenicity. Through electrostatic adsorption, <i>in situ</i> silicification and capping treatment, a hybrid coating of silica and PEI w ...[more]