Ontology highlight
ABSTRACT:
SUBMITTER: Tan EP
PROVIDER: S-EPMC5592672 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Tan Ee Phie EP McGreal Steven R SR Graw Stefan S Tessman Robert R Koppel Scott J SJ Dhakal Pramod P Zhang Zhen Z Machacek Miranda M Zachara Natasha E NE Koestler Devin C DC Peterson Kenneth R KR Thyfault John P JP Swerdlow Russell H RH Krishnamurthy Partha P DiTacchio Luciano L Apte Udayan U Slawson Chad C
The Journal of biological chemistry 20170724 36
Dysfunctional mitochondria and generation of reactive oxygen species (ROS) promote chronic diseases, which have spurred interest in the molecular mechanisms underlying these conditions. Previously, we have demonstrated that disruption of post-translational modification of proteins with β-linked <i>N</i>-acetylglucosamine (<i>O</i>-GlcNAcylation) via overexpression of the <i>O-</i>GlcNAc-regulating enzymes <i>O-</i>GlcNAc transferase (OGT) or <i>O-</i>GlcNAcase (OGA) impairs mitochondrial functio ...[more]