Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus.
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ABSTRACT:
SUBMITTER: Gautam S
PROVIDER: S-EPMC5592732 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus.
Gautam Samir S Kim Taehan T Lester Evan E Deep Deeksha D Spiegel David A DA
ACS chemical biology 20151105 1
Staphylococcus aureus is a Gram-positive bacterial pathogen that produces a range of infections including cellulitis, pneumonia, and septicemia. The principle mechanism in antistaphylococcal host defense is opsonization with antibodies and complement proteins, followed by phagocytic clearance. Here we use a previously developed technique for installing chemical epitopes in the peptidoglycan cell wall to show that surface glycopolymers known as wall teichoic acids conceal cell wall epitopes, prev ...[more]
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