Ontology highlight
ABSTRACT:
SUBMITTER: Karagiannis GS
PROVIDER: S-EPMC5592784 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Karagiannis George S GS Pastoriza Jessica M JM Wang Yarong Y Harney Allison S AS Entenberg David D Pignatelli Jeanine J Sharma Ved P VP Xue Emily A EA Cheng Esther E D'Alfonso Timothy M TM Jones Joan G JG Anampa Jesus J Rohan Thomas E TE Sparano Joseph A JA Condeelis John S JS Oktay Maja H MH
Science translational medicine 20170701 397
Breast cancer cells disseminate through TIE2/MENA<sup>Calc</sup>/MENA<sup>INV</sup>-dependent cancer cell intravasation sites, called tumor microenvironment of metastasis (TMEM), which are clinically validated as prognostic markers of metastasis in breast cancer patients. Using fixed tissue and intravital imaging of a PyMT murine model and patient-derived xenografts, we show that chemotherapy increases the density and activity of TMEM sites and Mena expression and promotes distant metastasis. Mo ...[more]