Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex.
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ABSTRACT:
SUBMITTER: Miri A
PROVIDER: S-EPMC5593145 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Behaviorally Selective Engagement of Short-Latency Effector Pathways by Motor Cortex.
Miri Andrew A Warriner Claire L CL Seely Jeffrey S JS Elsayed Gamaleldin F GF Cunningham John P JP Churchland Mark M MM Jessell Thomas M TM
Neuron 20170720 3
Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor cortical activity together with electromyography in mice during two forelimb movements that differ in their requirement for cortical involvement. Rapid optogenetic silencing and electrical stimula ...[more]
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