Ontology highlight
ABSTRACT:
SUBMITTER: Deshayes E
PROVIDER: S-EPMC5593411 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Deshayes Emmanuel E Roumiguie Mathieu M Thibault Constance C Beuzeboc Philippe P Cachin Florent F Hennequin Christophe C Huglo Damien D Rozet François F Kassab-Chahmi Diana D Rebillard Xavier X Houédé Nadine N
Drug design, development and therapy 20170906
Prostate cancer is the most common malignant disease in men. Several therapeutic agents have been approved during the last 10 years. Among them, radium-223 dichloride (Xofigo<sup>®</sup>) is a radioactive isotope that induces irreversible DNA double-strand breaks and consequently tumor cell death. Radium-223 dichloride is a calcium-mimetic agent that specifically targets bone lesions. Radium-223 dichloride has been approved for the treatment of metastatic castration-resistant prostate cancer wit ...[more]