NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia.

ABSTRACT: NiaoDuQing (NDQ) granules, a traditional Chinese medicine, has been clinically used in China for over fourteen years to treat chronic kidney disease (CKD). To elucidate the mechanisms underlying the therapeutic benefits of NDQ, we designed an approach incorporating chemoinformatics, bioinformatics, network biology methods, and cellular and molecular biology experiments. A total of 182 active compounds were identified in NDQ granules, and 397 putative targets associated with different diseases were derived through ADME modelling and target prediction tools. Protein-protein interaction networks of CKD-related and putative NDQ targets were constructed, and 219 candidate targets were identified based on topological features. Pathway enrichment analysis showed that the candidate targets were mo

SUBMITTER: Wang X 

PROVIDER: S-EPMC5593534 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature