Ontology highlight
ABSTRACT:
SUBMITTER: Pena-Oyarzun D
PROVIDER: S-EPMC5593539 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Peña-Oyarzun Daniel D Troncoso Rodrigo R Kretschmar Catalina C Hernando Cecilia C Budini Mauricio M Morselli Eugenia E Lavandero Sergio S Criollo Alfredo A
Oncotarget 20170705 34
Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several types of stress. Osmotic stress occurs under both physiological and pathological conditions, provoking mechanical stress and activating various osmoadaptive mechanisms. Polycystin-2 (PC2), a membrane protein of the polycystin family, is a mechanical sensor capable of activating ...[more]