Ontology highlight
ABSTRACT:
SUBMITTER: Barzago MM
PROVIDER: S-EPMC5593953 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Barzago Maria Monica MM Kurosaki Mami M Fratelli Maddalena M Bolis Marco M Giudice Chiara C Nordio Laura L Cerri Elisa E Domenici Luciano L Terao Mineko M Garattini Enrico E
Scientific reports 20170911 1
We generated 6 transgenic lines with insertion of an expression plasmid for the R883/M xanthine dehydrogenase (XDH) mutant protein. Approximately 20% of the animals deriving from one of the transgenic lines show ocular abnormalities and an increase in intra-ocular pressure which are consistent with glaucoma. The observed pathologic phenotype is not due to expression of the transgene, but rather the consequence of the transgene insertion site, which has been defined by genome sequencing. The inse ...[more]