Ontology highlight
ABSTRACT:
SUBMITTER: Lai RZ
PROVIDER: S-EPMC5594695 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Lai Run-Zhi RZ Han Xue-Sheng XS Dahlquist Frederick W FW Parkinson John S JS
Proceedings of the National Academy of Sciences of the United States of America 20170821 36
A sensory adaptation system that tunes chemoreceptor sensitivity enables motile <i>Escherichia coli</i> cells to track chemical gradients with high sensitivity over a wide dynamic range. Sensory adaptation involves feedback control of covalent receptor modifications by two enzymes: CheR, a methyltransferase, and CheB, a methylesterase. This study describes a CheR function that opposes the signaling consequences of its catalytic activity. In the presence of CheR, a variety of mutant serine chemor ...[more]