Ontology highlight
ABSTRACT:
SUBMITTER: Potelle S
PROVIDER: S-EPMC5595065 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Potelle Sven S Dulary Eudoxie E Climer Leslie L Duvet Sandrine S Morelle Willy W Vicogne Dorothée D Lebredonchel Elodie E Houdou Marine M Spriet Corentin C Krzewinski-Recchi Marie-Ange MA Peanne Romain R Klein André A de Bettignies Geoffroy G Morsomme Pierre P Matthijs Gert G Marquardt Thorsten T Lupashin Vladimir V Foulquier François F
The Biochemical journal 20170419 9
TMEM165 deficiencies lead to one of the congenital disorders of glycosylation (CDG), a group of inherited diseases where the glycosylation process is altered. We recently demonstrated that the Golgi glycosylation defect due to TMEM165 deficiency resulted from a Golgi manganese homeostasis defect and that Mn<sup>2+</sup> supplementation was sufficient to rescue normal glycosylation. In the present paper, we highlight TMEM165 as a novel Golgi protein sensitive to manganese. When cells were exposed ...[more]