Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi Y
PROVIDER: S-EPMC5595077 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Hayashi Yoshikazu Y Kawakubo-Yasukochi Tomoyo T Mizokami Akiko A Hazekawa Mai M Yakura Tomiko T Naito Munekazu M Takeuchi Hiroshi H Nakamura Seiji S Hirata Masato M
Journal of Cancer 20170802 13
Because of the poor response to chemotherapy and radiation therapy, new treatment approaches by immune-based therapy involving activated T cells are required for melanoma. We previously reported that the uncarboxylated form of osteocalcin (GluOC), derived from osteoblasts, potentially suppresses human prostate cancer cell proliferation by direct suppression of cell growth. However, the mechanisms <i>in vivo</i> have not been elucidated. In this study, we found that GluOC suppressed tumor growth ...[more]