Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Betancur JC
PROVIDER: S-EPMC5595439 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
García-Betancur Juan-Carlos JC García-Betancur Juan-Carlos JC Goñi-Moreno Angel A Horger Thomas T Schott Melanie M Sharan Malvika M Eikmeier Julian J Wohlmuth Barbara B Zernecke Alma A Ohlsen Knut K Kuttler Christina C Lopez Daniel D
eLife 20170912
A central question to biology is how pathogenic bacteria initiate acute or chronic infections. Here we describe a genetic program for cell-fate decision in the opportunistic human pathogen <i>Staphylococcus aureus</i>, which generates the phenotypic bifurcation of the cells into two genetically identical but different cell types during the course of an infection. Whereas one cell type promotes the formation of biofilms that contribute to chronic infections, the second type is planktonic and prod ...[more]