Ontology highlight
ABSTRACT:
SUBMITTER: Tsai HJ
PROVIDER: S-EPMC5595917 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Tsai Hui-Jen HJ Jiang Shih Sheng SS Hung Wen-Chun WC Borthakur Gautam G Lin Sheng-Fung SF Pemmaraju Naveen N Jabbour Elias E Bomalaski John S JS Chen Ya-Ping YP Hsiao Hui-Hua HH Wang Ming-Chung MC Kuo Ching-Yuan CY Chang Hung H Yeh Su-Peng SP Cortes Jorge J Chen Li-Tzong LT Chen Tsai-Yun TY
Scientific reports 20170912 1
Exogenous arginine is required for growth in some argininosuccinate synthetase (ASS)-deficient cancers. Arginine deiminase (ADI) inhibits growth in various ASS-deficient cancers by depleting arginine. The efficacy of pegylated ADI (ADI-PEG20) in relapsed/refractory/poor-risk acute myeloid leukemia (AML) was evaluated in 43 patients in a prospective, phase II trial (NCT01910012 (10/07/2013), https://clinicaltrials.gov/ct2/show/NCT01910012?term = ADI-PEG20&rank = 12 ). Despite almost all pre-treat ...[more]