Ontology highlight
ABSTRACT:
SUBMITTER: Thomas AA
PROVIDER: S-EPMC5596171 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Thomas Alissa A AA Abrey Lauren E LE Terziev Robert R Raizer Jeffrey J Martinez Nina L NL Forsyth Peter P Paleologos Nina N Matasar Matthew M Sauter Craig S CS Moskowitz Craig C Nimer Stephen D SD DeAngelis Lisa M LM Kaley Thomas T Grimm Sean S Louis David N DN Cairncross J Gregory JG Panageas Katherine S KS Briggs Samuel S Faivre Geraldine G Mohile Nimish A NA Mehta Jayesh J Jonsson Philip P Chakravarty Debyani D Gao Jianjiong J Schultz Nikolaus N Brennan Cameron W CW Huse Jason T JT Omuro Antonio A
Neuro-oncology 20171001 10
<h4>Background</h4>Anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) are chemotherapy-sensitive tumors with prolonged survival after radiochemotherapy. We report a prospective trial using induction temozolomide (TMZ) followed by myeloablative high-dose chemotherapy (HDC) with autologous stem-cell transplant (ASCT) as a potential strategy to defer radiotherapy.<h4>Methods</h4>Patients with AO/AOA received 6 cycles of TMZ (200 mg/m2 × 5/28 day). Responding patients were eligi ...[more]