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Osteonecrosis is unrelated to hip anatomy in children with acute lymphoblastic leukemia.

ABSTRACT: Osteonecrosis is a debilitating toxicity associated with acute lymphoblastic leukemia (ALL) treatment. A recent report associated interindividual differences in hip anatomy with the development of idiopathic osteonecrosis in adults. To evaluate the impact of hip anatomy on the development of therapy-related osteonecrosis, we retrospectively evaluated the femoral neck-shaft angle, femoral neck offset, and lateral center-edge angle using x-rays of 18 osteonecrosis cases and 46 control children treated for newly diagnosed ALL on a single protocol. Despite adequate statistical power, we found no association between hip anatomy and osteonecrosis. Investigation of other factors contributing to ALL-associated osteonecrosis is warranted.

SUBMITTER: Portera MV

PROVIDER: S-EPMC5596390 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Osteonecrosis is unrelated to hip anatomy in children with acute lymphoblastic leukemia.

Portera Mary V MV Karol Seth E SE Smith Colton C Yang Wenjian W Cheng Cheng C Neel Michael D MD Pui Ching-Hon CH Relling Mary V MV Kaste Sue C SC

Pediatric blood & cancer 20161230 7

Osteonecrosis is a debilitating toxicity associated with acute lymphoblastic leukemia (ALL) treatment. A recent report associated interindividual differences in hip anatomy with the development of idiopathic osteonecrosis in adults. To evaluate the impact of hip anatomy on the development of therapy-related osteonecrosis, we retrospectively evaluated the femoral neck-shaft angle, femoral neck offset, and lateral center-edge angle using x-rays of 18 osteonecrosis cases and 46 control children tre ...[more]

PMID: 28035753

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