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ABSTRACT: Background
HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical features of adult onset Still's disease (AOSD) in a Japanese population by determining the DRB1 allele distributions.Methods
DRB1 genotyping of 96 patients with AOSD and 1,026 healthy controls was performed. Genomic DNA samples from the AOSD patients were also genotyped for MEFV exons 1, 2, 3, and 10 by direct sequencing.Results
In Japanese patients with AOSD, we observed a predisposing association of DRB1*15:01 (p?=?8.60?×?10-6, corrected p (Pc)?=?0.0002, odds ratio (OR)?=?3.04, 95% confidence interval (95% CI)?=?1.91-4.84) and DR5 serological group (p?=?0.0006, OR?=?2.39, 95% CI?=?1.49-3.83) and a protective association of DRB1*09:01 (p?=?0.0004, Pc?=?0.0110, OR?=?0.34, 95% CI?=?0.18-0.66) with AOSD, and amino acid residues 86 and 98 of the DR? chain were protectively associated with AOSD. MEFV variants were identified in 49 patients with AOSD (56.3%). The predisposing effect of DR5 was confirmed only in patients with AOSD who had MEFV variants and not in those without MEFV variants. Additionally, DR5 in patients with AOSD are associated with macrophage activation syndrome (MAS) and steroid pulse therapy.Conclusion
The DRB1*15:01 and DR5 are both associated with AOSD susceptibility in Japanese subjects. A protective association between the DRB1*09:01 allele and AOSD was also observed in these patients. Our data also highlight the effects of DRB1 alleles in susceptibility to AOSD.
SUBMITTER: Asano T
PROVIDER: S-EPMC5596459 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Asano Tomoyuki T Furukawa Hiroshi H Sato Shuzo S Yashiro Makiko M Kobayashi Hiroko H Watanabe Hiroshi H Suzuki Eiji E Ito Tomoyuki T Ubara Yoshifumi Y Kobayashi Daisuke D Iwanaga Nozomi N Izumi Yasumori Y Fujikawa Keita K Yamasaki Satoshi S Nakamura Tadashi T Koga Tomohiro T Shimizu Toshimasa T Umeda Masataka M Nonaka Fumiaki F Yasunami Michio M Ueki Yukitaka Y Eguchi Katsumi K Tsuchiya Naoyuki N Tohma Shigeto S Yoshiura Koh-Ichiro KI Ohira Hiromasa H Kawakami Atsushi A Migita Kiyoshi K
Arthritis research & therapy 20170912 1
<h4>Background</h4>HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical features of adult onset Still's disease (AOSD) in a Japanese population by determining the DRB1 allele distributions.<h4>Methods</h4>DRB1 genotyping of 96 patients with AOSD and 1,026 healthy controls was performed. Genomic DNA samples from the AOSD patients were also genotyped for MEFV exons 1, 2, 3 ...[more]