Ontology highlight
ABSTRACT:
SUBMITTER: Wijeratne PA
PROVIDER: S-EPMC5597211 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wijeratne Peter A PA Hipwell John H JH Hawkes David J DJ Stylianopoulos Triantafyllos T Vavourakis Vasileios V
PloS one 20170913 9
We present an in-silico model of avascular poroelastic tumour growth coupled with a multiscale biphasic description of the tumour-host environment. The model is specified to in-vitro data, facilitating biophysically realistic simulations of tumour spheroid growth into a dense collagen hydrogel. We use the model to first confirm that passive mechanical remodelling of collagen fibres at the tumour boundary is driven by solid stress, and not fluid pressure. The model is then used to demonstrate the ...[more]