Ontology highlight
ABSTRACT:
SUBMITTER: Salles EM
PROVIDER: S-EPMC5597262 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Salles Érika Machado de ÉM Menezes Maria Nogueira de MN Siqueira Renan R Borges da Silva Henrique H Amaral Eduardo Pinheiro EP Castillo-Méndez Sheyla Inés SI Cunha Isabela I Cassado Alexandra Dos Anjos ADA Vieira Flávia Sarmento FS Olivieri David Nicholas DN Tadokoro Carlos Eduardo CE Alvarez José Maria JM Coutinho-Silva Robson R D'Império-Lima Maria Regina MR
PLoS pathogens 20170831 8
A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria. However, it is still unclear whether recognition of damage signals influences the immune response to Plasmodium infection. Adenosine triphosphate (ATP) accumulates in infected erythrocytes and is released into the extracellular milieu through ion channels in the erythrocyte membrane or upon erythrocyte rupture. The P2X7 receptor senses extrac ...[more]