Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure.

ABSTRACT: Vδ2⁺ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria. The role of these cells in mediating clinical immunity (i.e. protection against symptoms) to malaria remains unclear. We measured Vδ2⁺ T cell absolute counts at acute and convalescent malaria timepoints (n = 43), and Vδ2⁺ counts, cellular phenotype, and cytokine production following in vitro stimulation at asymptomatic visits (n = 377), among children aged 6 months to 10 years living in Uganda. Increasing age was associated with diminished in vivo expansion following malaria, and lower Vδ2 absolute counts overall, among children living in a high transmission s

SUBMITTER: Jagannathan P 

PROVIDER: S-EPMC5597587 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature