Renin-angiotensin system gene polymorphisms and high blood pressure in Lithuanian children and adolescents.

ABSTRACT:

Background

Epidemiological studies have demonstrated the influence of environmental factors on HBP in the population of Lithuanian children, although the role of genetic factors in hypertension has not yet been studied. The aim of this study was to assess the distribution of AGTR1, AGT, and ACE genotypes in the Lithuanian child population and to determine whether these genotypes have an impact on HBP in childhood.

Methods

This cross-sectional study enrolled 709 participants aged 12-15 years. The subjects were genotyped for AGT (M235 T, rs699), AGTR1 (A1166C, rs5186), and ACE (rs4340) gene polymorphisms using real-time and conventional polymerase chain reactions. Blood pressure and anthropometric parameters were measured.

Results

The prevalence of HBP was 38.6% and was

SUBMITTER: Simonyte S 

PROVIDER: S-EPMC5598068 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature