Ontology highlight
ABSTRACT:
SUBMITTER: Lu AQ
PROVIDER: S-EPMC5599185 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Lu Amy Q AQ Popova Evgenya Y EY Barnstable Colin J CJ
Stem cell reports 20170803 3
In vitro differentiation of mouse embryonic stem cells (ESCs) into retinal fates can be used to study the roles of exogenous factors acting through multiple signaling pathways during retina development. Application of activin A during a specific time frame that corresponds to early embryonic retinogenesis caused increased generation of CRX<sup>+</sup> photoreceptor precursors and decreased PAX6<sup>+</sup> retinal progenitor cells (RPCs). Following activin A treatment, SMAD2/3 was activated in R ...[more]