Ontology highlight
ABSTRACT:
SUBMITTER: Smallwood HS
PROVIDER: S-EPMC5599215 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Smallwood Heather S HS Duan Susu S Morfouace Marie M Rezinciuc Svetlana S Shulkin Barry L BL Shelat Anang A Zink Erika E EE Milasta Sandra S Bajracharya Resha R Oluwaseum Ajayi J AJ Roussel Martine F MF Green Douglas R DR Pasa-Tolic Ljiljana L Thomas Paul G PG
Cell reports 20170501 8
Influenza is a worldwide health and financial burden posing a significant risk to the immune-compromised, obese, diabetic, elderly, and pediatric populations. We identified increases in glucose metabolism in the lungs of pediatric patients infected with respiratory pathogens. Using quantitative mass spectrometry, we found metabolic changes occurring after influenza infection in primary human respiratory cells and validated infection-associated increases in c-Myc, glycolysis, and glutaminolysis. ...[more]