Ontology highlight
ABSTRACT:
SUBMITTER: Du Pre BC
PROVIDER: S-EPMC5599230 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Du Pré Bastiaan C BC Demkes Evelyne J EJ Feyen Dries A M DAM Dierickx Pieterjan P Crnko Sandra S Kok Bart J M BJM Sluijter Joost P G JPG Doevendans Pieter A PA Vos Marc A MA Van Veen Toon A B TAB Van Laake Linda W LW
Stem cell reports 20170810 3
Stem cell antigen 1-positive (SCA1<sup>+</sup>) cells (SPCs) have been investigated in cell-based cardiac repair and pharmacological research, although improved cardiac function after injection has been variable and the mode of action remains unclear. Circadian (24-hr) rhythms are biorhythms regulated by molecular clocks that play an important role in (patho)physiology. Here, we describe (1) the presence of a molecular circadian clock in SPCs and (2) circadian rhythmicity in SPC function. We iso ...[more]