Ontology highlight
ABSTRACT:
SUBMITTER: Langston LD
PROVIDER: S-EPMC5599239 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Langston Lance D LD Mayle Ryan R Schauer Grant D GD Yurieva Olga O Zhang Daniel D Yao Nina Y NY Georgescu Roxana E RE O'Donnell Mike E ME
eLife 20170904
Replicative helicases in all cell types are hexameric rings that unwind DNA by steric exclusion in which the helicase encircles the tracking strand only and excludes the other strand from the ring. This mode of translocation allows helicases to bypass blocks on the strand that is excluded from the central channel. Unlike other replicative helicases, eukaryotic CMG helicase partially encircles duplex DNA at a forked junction and is stopped by a block on the non-tracking (lagging) strand. This rep ...[more]