Ontology highlight
ABSTRACT:
SUBMITTER: Romano KA
PROVIDER: S-EPMC5599363 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Romano Kymberleigh A KA Martinez-Del Campo Ana A Kasahara Kazuyuki K Chittim Carina L CL Vivas Eugenio I EI Amador-Noguez Daniel D Balskus Emily P EP Rey Federico E FE
Cell host & microbe 20170824 3
Choline is an essential nutrient and methyl donor required for epigenetic regulation. Here, we assessed the impact of gut microbial choline metabolism on bacterial fitness and host biology by engineering a microbial community that lacks a single choline-utilizing enzyme. Our results indicate that choline-utilizing bacteria compete with the host for this nutrient, significantly impacting plasma and hepatic levels of methyl-donor metabolites and recapitulating biochemical signatures of choline def ...[more]