Ontology highlight
ABSTRACT:
SUBMITTER: MacNicol MC
PROVIDER: S-EPMC5599597 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
MacNicol Melanie C MC Cragle Chad E CE McDaniel F Kennedy FK Hardy Linda L LL Wang Yan Y Arumugam Karthik K Rahmatallah Yasir Y Glazko Galina V GV Wilczynska Ania A Childs Gwen V GV Zhou Daohong D MacNicol Angus M AM
Scientific reports 20170914 1
The Musashi family of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation predominantly through translational repression of mRNAs encoding pro-differentiation factors and inhibitors of cell cycle progression. During tissue development and repair however, Musashi repressor function must be dynamically regulated to allow cell cycle exit and differentiation. The mechanism by which Musashi repressor function is attenuated has not been fully established. Our pri ...[more]