Ontology highlight
ABSTRACT:
SUBMITTER: Manasa J
PROVIDER: S-EPMC5599673 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Manasa Justen J Varghese Vici V Pond Sergei L Kosakovsky SLK Rhee Soo-Yon SY Tzou Philip L PL Fessel W Jeffrey WJ Jang Karen S KS White Elizabeth E Rögnvaldsson Thorsteinn T Katzenstein David A DA Shafer Robert W RW
Scientific reports 20170914 1
Several groups have proposed that genotypic determinants in gag and the gp41 cytoplasmic domain (gp41-CD) reduce protease inhibitor (PI) susceptibility without PI-resistance mutations in protease. However, no gag and gp41-CD mutations definitively responsible for reduced PI susceptibility have been identified in individuals with virological failure (VF) while receiving a boosted PI (PI/r)-containing regimen. To identify gag and gp41 mutations under selective PI pressure, we sequenced gag and/or ...[more]