Dataset Information

Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.

ABSTRACT: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear.We examine the relationship between global histone concentrations and various markers of blood pressure.Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, H3K9me3, H3K27me3, and H3K36me3) associations with pre- and post-work measurements of systolic (SBP) and diastolic (DBP) blood pressure, mean arterial pressure (MAP), and pulse pressure (PP) using multivariable mixed-effect models.H3K9ac was negatively associated with pre-work SBP and MAP; H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP; and H3K27me3 was negatively associated with pre-work SBP. Among office workers, H3K9me3 was negatively associated with pre-work SBP, DBP, and MAP. Among truck drivers, H3K9ac and H3K27me were negatively associated with pre-work SBP, and H3K27me3 was positively associated with post-work PP.Epigenome-wide H3K9ac, H3K9me3, and H3K27me3 were negatively associated with multiple pre-work blood pressure measures. These associations substantially changed during the day, suggesting an influence of daily activities. Blood-based histone modification biomarkers are potential candidates for studies requiring estimations of morning/pre-work blood pressure.

SUBMITTER: Kresovich JK

PROVIDER: S-EPMC5599708 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.

Kresovich Jacob K JK Zhang Zhou Z Fang Fang F Zheng Yinan Y Sanchez-Guerra Marco M Joyce Brian T BT Zhong Jia J Chervona Yana Y Wang Sheng S Chang Dou D McCracken John P JP Díaz Anaite A Bonzini Matteo M Carugno Michele M Koutrakis Petros P Kang Choong-Min CM Bian Shurui S Gao Tao T Byun Hyang-Min HM Schwartz Joel J Baccarelli Andrea A AA Hou Lifang L

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20170726 6

<h4>Context</h4>Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear.<h4>Objective</h4>We examine the relationship between global histone concentrations and various markers of blood pressure.<h4>Materials and methods</h4>Using the Beijing Truck Driver Air Pollution Study, we investigated global peripheral white blood cell histone modifications (H3K9ac, ...[more]

PMID: 28678539

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Project description:BackgroundPost-transcriptional modifications of RNA constitute fundamental mechanisms of gene regulation. N6-methyladenosine (m6A) is critical for health and disease and is modulated by cellular stressors. However, associations between environmental exposures and m6A have not been studied in humans. We aimed to examine associations between tobacco smoking and particulate air pollution with m6A and mRNA expression levels of its reader, writer and eraser (RWE) genes in blood.MethodsUsing the Beijing Truck Driver Air Pollution Study, we investigated global m6A in RNA from peripheral blood collected from 106 human subjects in Beijing, China, in 2008. We measured m6A with nano-flow liquid chromatography-tandem mass spectrometry and investigated gene expression of six m6A RWEs with real-time-quantitative PCR. Using linear models, we examined associations with smoking status, pack-years, and smoking on day of visit in men, and with environmental tobacco smoke in nonsmokers. We also examined associations with ambient PM10 (particulate matter ≤ 10 µm in diameter), and personal black carbon (BC) and PM2.5 measured with a portable monitor.ResultsSmoking in men was significantly associated with a relative 10.7% decrease in global m6A levels in comparison to nonsmokers (p = 0.02). In men, smoking greater than 3.8 pack-years was associated with a 14.9% lower m6A than in nonsmokers. BC exposure trended towards positive associations with m6A (5.95% per 10 μg/m3 increase in BC; 95% CI: -0.96, 13.3). Global m6A levels were not correlated with RWE gene expression levels. No associations were detected between smoking or air pollutants and m6A RWE gene expression.Discussionm6A was negatively associated with long-term smoking, yet positively associated with short-term BC exposure. These results indicate variable m6A responses to environmental stressors, providing early evidence into the impacts of toxicants on RNA modifications and suggesting potential for m6A as a biomarker or mechanism in environmental health research.

Dataset Information

Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.

Publications

Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.

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