Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC5600063 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zhou Y Y Ingelman-Sundberg M M Lauschke V M VM
Clinical pharmacology and therapeutics 20170526 4
Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic activity toward a plethora of clinically important medications. Thus, single nucleotide variants and copy number variations in CYP genes are major determinants of drug pharmacokinetics and toxicity and constitute pharmacogenetic biomarkers for drug dosing, efficacy, and safety. Strikingly, the distribution of CYP alleles differs considerably between populations with important implications for personalized drug t ...[more]