Ontology highlight
ABSTRACT:
SUBMITTER: Fidler TP
PROVIDER: S-EPMC5600478 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Fidler Trevor P TP Campbell Robert A RA Funari Trevor T Dunne Nicholas N Balderas Angeles Enrique E Middleton Elizabeth A EA Chaudhuri Dipayan D Weyrich Andrew S AS Abel E Dale ED
Cell reports 20170701 4
Anucleate platelets circulate in the blood to facilitate thrombosis and diverse immune functions. Platelet activation leading to clot formation correlates with increased glycogenolysis, glucose uptake, glucose oxidation, and lactic acid production. Simultaneous deletion of glucose transporter (GLUT) 1 and GLUT3 (double knockout [DKO]) specifically in platelets completely abolished glucose uptake. In DKO platelets, mitochondrial oxidative metabolism of non-glycolytic substrates, such as glutamate ...[more]