Ontology highlight
ABSTRACT:
SUBMITTER: Chang AY
PROVIDER: S-EPMC5600480 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cell reports 20170601 12
RNAi factors and their catalytic activities are essential for heterochromatin assembly in S. pombe. This has led to the idea that siRNAs can promote H3K9 methylation by recruiting the cryptic loci regulator complex (CLRC), also known as recombination in K complex (RIKC), to the nucleation site. The conserved RNA-binding protein Rct1 (AtCyp59/SIG-7) interacts with splicing factors and RNA polymerase II. Here we show that Rct1 promotes processing of pericentromeric transcripts into siRNAs via the ...[more]