Ontology highlight
ABSTRACT:
SUBMITTER: Chung TW
PROVIDER: S-EPMC5601640 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Chung Tae-Wook TW Kim Eun-Young EY Kim Seok-Jo SJ Choi Hee-Jung HJ Jang Se Bok SB Kim Keuk-Jun KJ Ha Sun-Hyung SH Abekura Fukushi F Kwak Choong-Hwan CH Kim Cheorl-Ho CH Ha Ki-Tae KT
Oncotarget 20170314 35
The oligosaccharides in human milk have various biological functions. However, the molecular mechanism(s) underlying the anti-angiogenic action of sialylated human milk oligosaccharides (HMOs) are still unclear. Here, we show that siallylactose (SL) found in human milk can inhibit the activation of vascular endothelial growth factor (VEGF)-mediated VEGF receptor-2 (VEGFR-2) by binding to its VEGF binding site (second and third IgG-like domains), thus blocking downstream signal activation. SL als ...[more]