Ontology highlight
ABSTRACT:
SUBMITTER: Ling B
PROVIDER: S-EPMC5601659 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Ling Binbing B Watt Kathleen K Banerjee Sunandan S Newsted Daniel D Truesdell Peter P Adams Jarrett J Sidhu Sachdev S SS Craig Andrew W B AWB
Oncotarget 20170509 35
Matrix metalloproteinase-14 (MMP-14) is a clinically relevant target in metastatic cancers due to its role in tumor progression and metastasis. Since active MMP-14 is localized on the cell surface, it is amenable to antibody-mediated blockade in cancer, and here we describe our efforts to develop novel inhibitory anti-MMP-14 antibodies. A phage-displayed synthetic humanized Fab library was screened against the extracellular domain of MMP-14 and a panel of MMP14-specific Fabs were identified. A l ...[more]