Ontology highlight
ABSTRACT:
SUBMITTER: Song JW
PROVIDER: S-EPMC5601663 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Oncotarget 20170407 35
Pancreatic cancer (PC), characterized by aggressive local invasion and metastasis, is one of the most malignant cancers. Gemcitabine is currently used as the standard drug for the treatment of advanced and metastatic PC, but with limited efficacy. In this study, we demonstrated that gemcitabine increased the expression of heparanase (HPA1), the only known mammalian endoglycosidase capable of cleaving heparan sulfate, both <i>in vitro</i> and <i>in vivo</i>. Furthermore, overexpression of HPA1 in ...[more]