Ontology highlight
ABSTRACT:
SUBMITTER: Zhu M
PROVIDER: S-EPMC5601699 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhu Mingjun M Ma Xiaoqian X Cui Xiyao X Zhou Jing J Li Chengui C Huang Libo L Shang Yingli Y Cheng Ziqiang Z
Oncotarget 20170719 35
CCCH type zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the replication of a variety of viruses in mammals. However, little is known about its antiviral activity on avian tumor virus. Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, induces myelocytomas and various other tumors in meat and egg type chickens. Here, we identified a chicken ZAP (chZAP) that increased at early stage, and subsequently decreased after infection of ALV-J in DF-1 cells, ...[more]