Ontology highlight
ABSTRACT:
SUBMITTER: Qu C
PROVIDER: S-EPMC5602043 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Qu Changbo C Xu Lei L Yin Yuebang Y Peppelenbosch Maikel P MP Pan Qiuwei Q Wang Wenshi W
Archives of virology 20170616 10
Hepatitis E virus (HEV) infection has emerged as a global health issue, but no approved medication is available. The nucleoside analogue 2'-C-methylcytidine (2CMC), a viral polymerase inhibitor, has been shown to inhibit infection with a variety of viruses, including hepatitis C virus (HCV). Here, we report that 2CMC significantly inhibits the replication of HEV in a subgenomic replication model and in a system using a full-length infectious virus. Importantly, long-term treatment with 2CMC did ...[more]