Ontology highlight
ABSTRACT:
SUBMITTER: Dussault AM
PROVIDER: S-EPMC5602112 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20170712 10
Riboswitches are noncoding mRNA elements that control gene expression by altering their structure upon metabolite binding. Although riboswitch crystal structures provide detailed information about RNA-ligand interactions, little knowledge has been gathered to understand how riboswitches modulate gene expression. Here, we study the molecular recognition mechanism of the <i>S</i>-adenosylmethionine SAM-I riboswitch by characterizing the formation of a helical stacking interaction involving the lig ...[more]