Ontology highlight
ABSTRACT:
SUBMITTER: Mages CF
PROVIDER: S-EPMC5602299 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Mages Christina Fs CF Wintsche Axel A Bernhart Stephan H SH Müller Gerd A GA
eLife 20170918
The retinoblastoma Rb protein is an important factor controlling the cell cycle. Yet, mammalian cells carrying Rb deletions are still able to arrest under growth-limiting conditions. The Rb-related proteins p107 and p130, which are components of the DREAM complex, had been suggested to be responsible for a continued ability to arrest by inhibiting E2f activity and by recruiting chromatin-modifying enzymes. Here, we show that p130 and p107 are not sufficient for DREAM-dependent repression. We ide ...[more]