Ontology highlight
ABSTRACT:
SUBMITTER: Yuan D
PROVIDER: S-EPMC5603188 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Yuan Dongfen D Zhao Yuling Y Banks William A WA Bullock Kristin M KM Haney Matthew M Batrakova Elena E Kabanov Alexander V AV
Biomaterials 20170710
Recent work has stimulated interest in the use of exosomes as nanocarriers for delivery of small drugs, RNAs, and proteins to the central nervous system (CNS). To overcome the blood-brain barrier (BBB), exosomes were modified with brain homing peptides that target brain endothelium but likely to increase immune response. Here for the first time we demonstrate that there is no need for such modification to penetrate the BBB in mammals. The naïve macrophage (Mϕ) exosomes can utilize, 1) on the one ...[more]