Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin.
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ABSTRACT:
SUBMITTER: Waldhart AN
PROVIDER: S-EPMC5603216 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
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Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin.
Waldhart Althea N AN Dykstra Holly H Peck Anderson S AS Boguslawski Elissa A EA Madaj Zachary B ZB Wen Jennifer J Veldkamp Kelsey K Hollowell Matthew M Zheng Bin B Cantley Lewis C LC McGraw Timothy E TE Wu Ning N
Cell reports 20170601 10
Growth factors, such as insulin, can induce both acute and long-term glucose uptake into cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT)4 storage vesicles with the cell surface that occurs in muscle and adipose tissues, the mechanism behind acute induction has been unclear in other systems. Thioredoxin interacting protein (TXNIP) has been shown to be a negative regulator of cellular glucose uptake. TXNIP is transcriptionally induced by glucose and reduces glucos ...[more]
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