Ontology highlight
ABSTRACT:
SUBMITTER: Guo P
PROVIDER: S-EPMC5603366 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Guo Peng P Yang Jiang J Bielenberg Diane R DR Dillon Deborah D Zurakowski David D Moses Marsha A MA Auguste Debra T DT
Journal of controlled release : official journal of the Controlled Release Society 20170322
Identifying a molecular target is essential for tumor-targeted nanomedicine. Current cancer nanomedicines commonly suffer from poor tumor specificity, "off-target" toxicity, and limited clinical efficacy. Here, we report a method to screen and identify new molecular targets for tumor-targeted nanomedicine based on a quantitative analysis. In our proof-of-principle study, we used comparative flow cytometric screening to identify ICAM-1 as a potential target for metastatic melanoma (MM). We furthe ...[more]