Hypertelorism and Orofacial Clefting Revisited: An Anthropometric Investigation.

ABSTRACT:

Objective

Since the 1960s, multiple studies have reported a tendency toward hypertelorism in individuals with nonsyndromic orofacial clefts (OFCs). However, the association between specific cleft types and increased interorbital distance has been inconsistent. Using three-dimensional (3D) surface imaging, we tested whether different forms of clefting showed evidence of increased interorbital distance.

Methods

Intercanthal and outercanthal distances and intercanthal indices were calculated from 3D facial surface images of 287 individuals with repaired OFCs. Raw measurements were converted to sex and age-normalized Z-scores. Mean Z-scores for individuals with cleft lip (CL), cleft lip and palate (CLP), and cleft palate (CP) were compared with reference normative values (contro

SUBMITTER: Weinberg SM 

PROVIDER: S-EPMC5603419 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature