Ontology highlight
ABSTRACT:
SUBMITTER: Homman-Ludiye J
PROVIDER: S-EPMC5603509 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Homman-Ludiye Jihane J Kwan William C WC de Souza Mitchell J MJ Rodger Jennifer J Bourne James A JA
Scientific reports 20170918 1
The development of the neocortex requires co-ordination between proliferation and differentiation, as well as the precise orchestration of neuronal migration. Eph/ephrin signaling is crucial in guiding neurons and their projections during embryonic development. In adult ephrin-A2 knockout mice we consistently observed focal patches of disorganized neocortical laminar architecture, ranging in severity from reduced neuronal density to a complete lack of neurons. Loss of ephrin-A2 in the pre-optic ...[more]