Unknown

Dataset Information

0

Variations in oral microbiota associated with oral cancer.


ABSTRACT: Individual bacteria and shifts in microbiome composition are associated with human disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis and oral squamous cell carcinoma (OSCC), cancer lesion samples and anatomically matched normal samples were obtained from the same patients. We then profiled the bacteria within OSCC lesion surface samples at the species level using next-generation sequencing to comprehensively investigate bacterial community composition and functional genes in these samples. Significantly greater bacterial diversity was observed in the cancer samples than in the normal samples. Compared with previous studies, we identified many more taxa demonstrating remarkably different distributions between the groups. In particular, a group of periodontitis-correlated taxa, including Fusobacterium, Dialister, Peptostreptococcus, Filifactor, Peptococcus, Catonella and Parvimonas, was significantly enriched in OSCC samples. Additionally, several operational taxonomic units (OTUs) associated with Fusobacterium were highly involved in OSCC and demonstrated good diagnostic power. Our study revealed drastic changes in surface bacterial communities of OSCC. The findings enrich knowledge of the association between oral bacterial communities and oral cancer.

SUBMITTER: Zhao H 

PROVIDER: S-EPMC5603520 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Variations in oral microbiota associated with oral cancer.

Zhao Hongsen H   Chu Min M   Huang Zhengwei Z   Yang Xi X   Ran Shujun S   Hu Bin B   Zhang Chenping C   Liang Jingping J  

Scientific reports 20170918 1


Individual bacteria and shifts in microbiome composition are associated with human disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis and oral squamous cell carcinoma (OSCC), cancer lesion samples and anatomically matched normal samples were obtained from the same patients. We then profiled the bacteria within OSCC lesion surface samples at the species level using next-generation sequencing to comprehensively investigate bacterial community composition and  ...[more]

Similar Datasets

| S-EPMC6618584 | biostudies-literature
| S-EPMC4041887 | biostudies-literature
| PRJEB12021 | ENA
| S-EPMC6692966 | biostudies-literature
| S-EPMC6974454 | biostudies-literature
| S-EPMC9051480 | biostudies-literature
| S-EPMC5943489 | biostudies-literature
| S-EPMC8117382 | biostudies-literature
| S-EPMC3372458 | biostudies-other
| S-EPMC6624419 | biostudies-literature