Ontology highlight
ABSTRACT:
SUBMITTER: Stahlhut SG
PROVIDER: S-EPMC5603545 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Stahlhut Steen G SG Alqarzaee Abdulelah A AA Jensen Camilla C Fisker Niclas S NS Pereira Ana R AR Pinho Mariana G MG Thomas Vinai Chittezham VC Frees Dorte D
Scientific reports 20170918 1
In living cells intracellular proteolysis is crucial for protein homeostasis, and ClpP proteases are conserved between eubacteria and the organelles of eukaryotic cells. In Staphylococcus aureus, ClpP associates to the substrate specificity factors, ClpX and ClpC forming two ClpP proteases, ClpXP and ClpCP. To address how individual ClpP proteases impact cell physiology, we constructed a S. aureus mutant expressing ClpX with an I<sub>265</sub>E substitution in the ClpP recognition tripeptide of ...[more]