Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5603557 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Liu Yicong Y Wu Zhou Z Nakanishi Yurika Y Ni Junjun J Hayashi Yoshinori Y Takayama Fumiko F Zhou Yanmin Y Kadowaki Tomoko T Nakanishi Hiroshi H
Scientific reports 20170918 1
Despite a clear correlation between periodontitis and cognitive decline in Alzheimer's disease, the precise mechanism underlying the relationship remains unclear. The periodontal pathogen Porphyromonas gingivalis produces a unique class of cysteine proteinases termed gingipains that comprises Arg-gingipain (Rgp) and Lys-gingipain (Kgp). Rgp and Kgp are important in the bacterial mediated host cell responses and the subsequent intracellular signaling in infected cells. In the present study, we at ...[more]