Prenatal Glucocorticoid Exposure Modifies Endocrine Function and Behaviour for 3 Generations Following Maternal and Paternal Transmission.
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ABSTRACT:
SUBMITTER: Moisiadis VG
PROVIDER: S-EPMC5603559 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
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Prenatal Glucocorticoid Exposure Modifies Endocrine Function and Behaviour for 3 Generations Following Maternal and Paternal Transmission.
Moisiadis Vasilis G VG Constantinof Andrea A Kostaki Alisa A Szyf Moshe M Matthews Stephen G SG
Scientific reports 20170918 1
Fetal exposure to high levels of glucocorticoids programs long-term changes in the physiologic stress response and behaviours. However, it is not known whether effects manifest in subsequent generations of offspring following maternal (MT) or paternal (PT) transmission. We treated pregnant guinea pigs with three courses of saline or synthetic glucocorticoid (sGC) at a clinically relevant dose. Altered cortisol response to stress and behaviours transmitted to juvenile female and male F<sub>2</sub ...[more]
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